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The Poholek Lab

The Poholek Lab for Molecular Immune Cell Research

Assessing How Transcriptomics and Epigenetics Contribute to Health and Disease

Immune cells, such as T cells, play a critical role in establishing and maintaining whole organism health, while aberrant immune cell function underlies a host of diseases ranging from immunodeficiency to autoimmunity. As a model system for cellular differentiation, immune cells have the unique property of both maintaining homeostasis and responding to environmental or pathogenic insult.

Using NextGen sequencing technologies, Amanda Poholek, PhD, and her team of researchers are seeking to understand how tissue-specific environments control T cell differentiation and function at the transcriptomic and epigenomic level to understand the greater impact of immune cell regulation on health and disease.